LDN193189 （Hydrochloride）
- 型號(hào)： HY-12071A
- 更新時(shí)間： 2024-06-03
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HY-12071A LDN193189鹽酸鹽（的同義詞LDN193189鹽酸鹽; LDN-193189鹽酸鹽）機(jī)制：ALK
LDN193189鹽酸鹽技術(shù)參數(shù)：價(jià)格和可用性LDN193189鹽酸鹽
LDN193189鹽酸鹽M.Wt：442.94
LDN193189鹽酸鹽分子式：C25H23ClN6
LDN193189的鹽酸純度：>98％
LDN193189鹽酸貯存：貯存在-20℃2年
LDN193189鹽酸鹽CAS號(hào)：1062368-62-0
LDN193189鹽酸鹽溶解性：DMSO
生物活性LDN193189鹽酸：
LDN193189是一種高度有效的小分子BMP抑制劑;抑制BMP I型受體ALK2（IC50：nM的5個(gè)），ALK3（IC50：30納米）和ALK6（TGFβ1/BMP信令）和隨后的SMAD蛋白的磷酸化; LDN193189是有用的工具中的干細(xì)胞生物學(xué)。 LDN193189顯示在體內(nèi)的臨床應(yīng)用價(jià)值，抑制FOP和異位骨化和潛在的代理人在治療非小細(xì)胞肺癌肺腫瘤具有重要意義。
HY-12071A LDN193189 hydrochloride (Synonyms LDN 193189 hydrochloride; LDN-193189 hydrochloride) Mechanisms:ALK
LDN193189 hydrochloride M.Wt: 442.94
LDN193189 hydrochloride Formula: C25H23ClN6
LDN193189 hydrochloride Purity: >98%
LDN193189 hydrochloride Storage: at -20℃ 2 years
LDN193189 hydrochloride CAS No.: 1062368-62-0
LDN193189 hydrochloride Solubility: DMSO
5mg
10mg
50mg
Biological Activity of LDN193189 hydrochloride:
LDN193189 is a highly potent small molecule BMP inhibitor; inhibiting BMP type I receptors ALK2 (IC50: 5 nM), ALK3 (IC50: 30 nM) and ALK6 (TGFβ1/BMP signaling) and subsequent SMAD phosphorylation; LDN193189 is useful tool in stem cell biology. LDN193189 shows significant in vivo clinical utility, inhibiting FOP and ectopic ossification and a potential agent in the treatment of NSCLC lung tumors.